COPPER DELIVERY TO THE CNS BY CUATSM EFFECTIVELY TREATS MOTOR NEURON DISEASE IN SODG93A MICE CO-EXPRESSING THE COPPER-CHAPERONE-FOR-SOD

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration.However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks.The Copper-Chaperone-for-SOD (CCS) protein completes the maturation of SOD by inserting copper, but paradoxic

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From Constant to Rough: A Survey of Continuous Volatility Modeling

In this paper, we present a comprehensive survey of continuous stochastic volatility models, discussing their historical development Fire Table and the key stylized facts that have driven the field.Special attention is dedicated to fractional and rough methods: without advocating for either roughness or long memory, we outline the motivation behind

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